Casein derivatives or compounds and process of making same.



a strong hydrochloric acid and dried. 1 kilo .kali or until the commencement of the acid i w "r in lblb i i/oh. RUDOLF TAMBACH, LUDWIGSIIAFEN-UN-THE-RHINE, GERMANY, ASSIGNUE TU THE FIRM OF KNOLL AND COMPANY, 011' LUDWIGSHAFEN-ON-THE-RHINE, GlsqltdidfiNY.

CASEIN DERIVATIVES 0R COMPOUNDS AND PROICESS OF MAKING SAME.

967,584. No Drawing.

Patented ftu (Specimens) Specification ot Letters Patent.

l ti,- littittl. Application filed April 10, 1908. Serial No. 426,340.

To all whom it may concern: gram of this chlorocesein derivative is Be it known that I, Ruoonr TAMBAGII, a stirred up with 10 litersoi water and subject of the German Emperor, residing at brought into solution by the nddition LudWigshafen-on-the Rhine, Germany, have{ caustic soda solution and then mixed with invented certain new and useful Casein 10 liters of n 10 per cent. solution of tannin. Derivatives ob flompounds and Process for The new compound thus formed is sepsrated the Manufacture'of the Same, of which the out by the addition of acids in the cold or following is a specification. in the heat, washed with water, dried, put

If alkali-hypochlorites or chlorin be 211- verized and sifted. lowed to act 1n the presence of excess of al Example II: 1 kilogram of chlorocasein derivative is dissolved in the sinoimt of di lute spirit necessary to disolve it, and trotted with l kilogram of tannin in allreline or aqueous solution. The new compound is so arated out by the addition of acidsnnd afls erward treated as above.

The alkaline liquor obtained in the chlorination of the casein may also be trented rectly with tannin solution and the new product separated out by acids.

The compounds of tannic acid with the new chlorinated casein derivutives are to used therapeutically in disorders oi? the in testines.

What I claim is:-

l. The compounds of chlorinated casein derivativw with tannic acid, which consists in treating the said chlorinated casein derivatives obmined by the action of chlorin on casein in alkaline solution, in solution with tannic acid, sepnratin out the compounds thus prouccd, with acids, was

reaction and in the cold or in the heat u on casein which has been dissolved in solutions of alkalies or alkali carbonates, simultaneous oxidation and chlorination of the casein takes place, with formation of new compounds, which are precipitated on the addition of acids. These casein derivatives possess po'weri'ul putrefaction-arresting properties, so that in week ulkalinesolutions for example, they revent the putrefaction of ancreas fob aye and weeks. This he evior would appear to render the prepare tions admirably suitable as intestinal antiseptics, if their small capability of resisting the 'uice of the stomach were not obstructive to t eir use.

I have found, that these new casein derivstives on treatment with tannic acid compounds unite with the latter and that these compounds are ca able oi resisting the juices of the stomac in a. high degree, but are soluble in water which has been rendered alkaline, so that the antiseptic roperties of the components can come into ull action in the intestines. The com ounds which can thus be prepared are ye lowish-gray powders. They are almost insoluble in water and dilute acids, but are easily soluble in alknlies. The a ueous decoction is colored blue by iron chlorid (ferric chlorid) solution and gives u. precipitate with a solution of egg-allow men; they. are insoluble in the cold in alcoholend in chemically inert solvents.

and drying, substantially as described.

2. As new products, compounds of chlorinated casein derivatives with tannic acid, the said. compound, being'obtainable as yellowish-gray powders, insoluble in cold alco 1101, almost insoluble in water and acids, soluble in allralies, assuming a blue color when treated in aqueous decoction with ferric chlorid, forming av recipitate with albumen solutions, and od bring great re sistance to the juices of the stomach, sub- Emnnple Ir 1 kilogram of casein is disstantially as described. solved by 10 litersof Water and 2 liters of a In testimony whereof I have hereunto set 20 per cent-caustic soda solution, the solumy hand in presence of two subscribing wittion hosted for two hours at to (3., with two liters of a 10 per cent. sodium unborn TAMJBAUH'.

hfypochlorite solution, then filtered from the s i ht residue, and the chloro-casein deriva- 'Witnesses:

tive is precipitated from the filtrate by HERMANN TAEGER,

Joe. H. LEUTE.

, tilt till ,hing them with water till in dilute 

